HPV16_entry_mechanism_1

HPV16_entry_mechanism_1
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Figure 5.1. Simplified proposed model of HPV16 attachment and entry into host cells.
The HPV16 PsV (magenta) attaches to heparin (HSPG substitute molecule; surface rendered in grey) around the pentavalent capsomere. Furin cleaves the L2 minor capsid protein (not shown). Subsequently, the L1 chains on the HPV16 capsid undergo a change in conformation, forming the furin cleaved HPV16 PsV capsid (blue). The HPV16 PsV then transfers to the secondary entry receptor or receptor complex, which may include the initial HSPG cell binding molecule (represented here by the heparin density) and is internalised into the cell.

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